Author Topic: Immune-mediated inflammatory diseases  (Read 14178 times)

Naman

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Re: Immune-mediated inflammatory diseases
« Reply #15 on: February 27, 2018, 12:30:49 PM »
I feel so bad reading the status of your health. I m not sure but cant deep meditation give some not yet known remedy for the issues u r having with ur health, the diabetes? I wish u speedy recovery from all the pain without having to amputate any Toes!!

Jhanananda

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Re: Immune-mediated inflammatory diseases
« Reply #16 on: February 27, 2018, 05:16:02 PM »
Thank-you, Naman, for expressing your kind thoughts for my recovery.  Yesterday I moved out of the van and into a trailer that a friend offered to me to stay in.  My health has improved considerably.  So, I am sure that the van was a disease vector for me.

In my experience deep meditation can be a very powerful tool for healing work.  I regularly use it on myself; and I have used it for decades for the treating of others.  Another use that deep meditation offers is insight.  I have used insight to work through the causes of my ill-health.  I am confident that when I can move from Prescott, AZ, then my health will improve.

The current plan is, once the deuce and a half is finished being brought up to road-worthy performance, then I plan to purchase a cab-over camper for it, and install solar panels on it, and travel about the sw USA.
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bodhimind

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Re: Immune-mediated inflammatory diseases
« Reply #17 on: February 28, 2018, 12:02:43 AM »
That sounds great, have you thought of washing out the van with betadine or alcohol?

I'm pretty interested in how deep meditation can be used for treating others as well.

Naman

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Re: Immune-mediated inflammatory diseases
« Reply #18 on: February 28, 2018, 08:05:33 AM »
Thank-you, Naman, for expressing your kind thoughts for my recovery.  Yesterday I moved out of the van and into a trailer that a friend offered to me to stay in.  My health has improved considerably.  So, I am sure that the van was a disease vector for me.

In my experience deep meditation can be a very powerful tool for healing work.  I regularly use it on myself; and I have used it for decades for the treating of others.  Another use that deep meditation offers is insight.  I have used insight to work through the causes of my ill-health.  I am confident that when I can move from Prescott, AZ, then my health will improve.

The current plan is, once the deuce and a half is finished being brought up to road-worthy performance, then I plan to purchase a cab-over camper for it, and install solar panels on it, and travel about the sw USA.
Thats great to hear that ur health is improved.
Im sure that meditation is also helping to improve ur body.
Whats the destination ? Anywhere specific are you aiming to go or will u keep moving around the location?

Jhanananda

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Re: Immune-mediated inflammatory diseases
« Reply #19 on: March 02, 2018, 04:13:56 PM »
Thank-you, bodhimind and Naman, for posting your comments and concern. The van is toast, so I do not plant to do anything with it, except to bake it out at about 120F to kill any molds or bugs in it.  I plan only to remove useful things out of it, then call the junkyard, and have them tow it away.

It is reasonable that regular access to deep meditation, as I have had for 45 years, may be good for one's health; nonetheless, my health problems seem to be an inherited autoimmune disorder; and associated with airborne allergens, so my current solution is to wear a respirator during the day, and sleep with a HEPA filter near my bed.  I am also now wearing swimmer's goggles to protect my eyes from airborne allergens. These three measures, in addition to evacuating the van, seem to have improved my health.

The plan is to hit the road as soon as I can get my deuce and a half running, and a camper on it, then I plan to travel until I find a place where I have fewer allergies.  In the past, it has required moving with the seasons.  So, I might just go back to that.

Yes, deep meditation can be used for healing self, and others.  We can discuss that under another topic thread.

This resent article supports my findings.

Type 2 Diabetes Was Misdiagnosed All Along, It Could Actually Be Several Diseases
Quote
What if diabetes wasn't just one condition with two types, but a whole bunch of diseases under the same label?

That's the conclusion of new research, and it could revolutionise the way we detect and treat diabetes in the future.

Analysing past studies covering a total of 14,775 type 1 and type 2 adult-onset diabetes patients across Sweden and Finland, scientists have found five different and distinct disease profiles, including three severe and two mild forms of the condition.

The more precise we can be about different categories of diabetes, the better we can understand and treat it, according to the team of researchers from Scandinavia

It might even give doctors an earlier window of opportunity for preventing the onset of diabetes.

"Evidence suggests that early treatment for diabetes is crucial to prevent life-shortening complications," says senior researcher Leif Groop, from the Lund University Diabetes Centre (LUDC) in Sweden.

"More accurately diagnosing diabetes could give us valuable insights into how it will develop over time, allowing us to predict and treat complications before they develop."

Six different measurements were used across four separate studies: age at diagnosis, body mass index (BMI), long-term glycaemic (blood sugar) control, the function of insulin-producing cells in the pancreas, insulin resistance, and the presence of specific autoantibodies linked to autoimmune diabetes.

Instead of splitting diabetes simply into type 1 and type 2, the researchers came up with five different disease profiles - one autoimmune type of diabetes and four other distinct subtypes. All five types were found to be genetically distinct, with no shared mutations.

This is enough to suggest we're looking at five distinct diseases that all affect the same body system, rather than the same disease at different stages of progression, say the researchers.

So how did they differ? One of the three more serious forms was a group of people with severe insulin resistance and a significantly higher risk of kidney disease. Another more mild type was seen mostly in elderly people.

You can see how those distinctions could improve the way we tackle diabetes – by identifying the types of patients involved and the complications they're at risk from, doctors could work out more personalised courses of treatment.

Indeed, the researchers found that many in the study weren't being given the right treatment for the particular characteristics of the diabetes they had.

With diabetes now the fastest-growing disease on the planet, more options for dealing with it can't come soon enough. More than 420 million people are now thought to have diabetes worldwide.

Between 75-85 percent of people with diabetes have the more common type 2, where the body can't produce enough insulin to cope with levels of insulin resistance.

The researchers do note some limitations though: there's no evidence yet that these five types of diabetes have different causes, and the sample only included Scandinavian patients, so a wider study is going to be required to investigate this further.

"Existing treatment guidelines are limited by the fact they respond to poor metabolic control when it has developed, but do not have the means to predict which patients will need intensified treatment," says Groop.

"This study moves us towards a more clinically useful diagnosis, and represents an important step towards precision medicine in diabetes."

The research has been published in The Lancet Diabetes & Endocrinology.
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Jhanananda

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Re: Immune-mediated inflammatory diseases
« Reply #20 on: April 16, 2018, 05:39:19 PM »
The original article on Autoimmune diabetes was published in Lancet:
Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

Quote
Summary
Background

Diabetes is presently classified into two main forms, type 1 and type 2 diabetes, but type 2 diabetes in particular is highly heterogeneous. A refined classification could provide a powerful tool to individualise treatment regimens and identify individuals with increased risk of complications at diagnosis.

Methods

We did data-driven cluster analysis (k-means and hierarchical clustering) in patients with newly diagnosed diabetes (n=8980) from the Swedish All New Diabetics in Scania cohort. Clusters were based on six variables (glutamate decarboxylase antibodies, age at diagnosis, BMI, HbA1c, and homoeostatic model assessment 2 estimates of β-cell function and insulin resistance), and were related to prospective data from patient records on development of complications and prescription of medication. Replication was done in three independent cohorts: the Scania Diabetes Registry (n=1466), All New Diabetics in Uppsala (n=844), and Diabetes Registry Vaasa (n=3485). Cox regression and logistic regression were used to compare time to medication, time to reaching the treatment goal, and risk of diabetic complications and genetic associations.

Findings

We identified five replicable clusters of patients with diabetes, which had significantly different patient characteristics and risk of diabetic complications. In particular, individuals in cluster 3 (most resistant to insulin) had significantly higher risk of diabetic kidney disease than individuals in clusters 4 and 5, but had been prescribed similar diabetes treatment. Cluster 2 (insulin deficient) had the highest risk of retinopathy. In support of the clustering, genetic associations in the clusters differed from those seen in traditional type 2 diabetes.

Interpretation

We stratified patients into five subgroups with differing disease progression and risk of diabetic complications. This new substratification might eventually help to tailor and target early treatment to patients who would benefit most, thereby representing a first step towards precision medicine in diabetes.

Funding

Swedish Research Council, European Research Council, Vinnova, Academy of Finland, Novo Nordisk Foundation, Scania University Hospital, Sigrid Juselius Foundation, Innovative Medicines Initiative 2 Joint Undertaking, Vasa Hospital district, Jakobstadsnejden Heart Foundation, Folkhälsan Research Foundation, Ollqvist Foundation, and Swedish Foundation for Strategic Research.
« Last Edit: April 17, 2018, 04:05:16 PM by Jhanananda »
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Jhanananda

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Re: Immune-mediated inflammatory diseases
« Reply #21 on: April 23, 2018, 04:15:19 PM »
Last week the local newspaper ran an article on the Prescott, AZ local allergy problem.  It claims that Prescott, AZ has the worst seasonal allergies of any city in the USA.  I believe it.

It has been a month since I was last in the hospital, and I am 2.5 weeks into full recovery, just from using HEPA filters in my trailer, and when I leave the trailer, then I now wear a full-face respirator.  It is all helping.  From disastrous experiments I have found that I can get away with a few minutes without the respirator, but an hour will result, during peak allergy season, in a health crisis.

Quote from: wiki
HEPA filter
High efficiency particulate air (HEPA),[1][2] originally called high-efficiency particulate absorber but also sometimes called high-efficiency particulate arresting or high-efficiency particulate arrestance, is a type of air filter. Filters meeting the HEPA standard have many applications, including use in medical facilities, automobiles, aircraft and homes. The filter must satisfy certain standards of efficiency such as those set by the United States Department of Energy (DOE).

To qualify as HEPA by industry standards, an air filter must remove (from the air that passes through) 99.97% of particles that have a size greater-than-or-equal-to 0.3 µm.[3] Although the ASME industry standard is not published by any government, it is recognized as an authoritative standard by many governments.

HEPA was commercialized in the 1950s, and the original term became a registered trademark and later a generic term for highly efficient filters.[4]

What they do
HEPA filters are composed of a mat of randomly arranged fibres.[5] The fibres are typically composed of fiberglass and possess diameters between 0.5 and 2.0 micrometers. Key factors affecting its functions are fibre diameter, filter thickness, and face velocity. The air space between HEPA filter fibres is typically much greater than 0.3 μm. The common assumption that a HEPA filter acts like a sieve where particles smaller than the largest opening can pass through is incorrect and impractical. Unlike membrane filters at this pore size, where particles as wide as the largest opening or distance between fibres can not pass in between them at all, HEPA filters are designed to target much smaller pollutants and particles. These particles are trapped (they stick to a fibre) through a combination of the following three mechanisms:

Interception
    where particles following a line of flow in the air stream come within one radius of a fibre and adhere to it.

Impaction
    where larger particles are unable to avoid fibres by following the curving contours of the air stream and are forced to embed in one of them directly; this effect increases with diminishing fibre separation and higher air flow velocity.

Diffusion
    an enhancing mechanism that is a result of the collision with gas molecules by the smallest particles, especially those below 0.1 µm in diameter, which are thereby impeded and delayed in their path through the filter; this behaviour is similar to Brownian motion and raises the probability that a particle will be stopped by either of the two mechanisms above; this mechanism becomes dominant at lower air flow velocities.

Diffusion predominates below the 0.1 μm diameter particle size. Impaction and interception predominate above 0.4 μm. [6] In between, near the most penetrating particle size (MPPS) 0.21 μm, both diffusion and interception are comparatively inefficient.[7] Because this is the weakest point in the filter's performance, the HEPA specifications use the retention of particles near this size (0.3 μm) to classify the filter.[6] However it is possible for particles smaller than the MPPS to not have filtering efficiency greater than that of the MPPS. This is due to the fact that these particles can act as nucleation sites for mostly condensation and form particles near the MPPS.[7]

Lastly, it is important to note that HEPA filters are designed to arrest very fine particles effectively, but they do not filter out gasses and odor molecules. Circumstances requiring filtration of volatile organic compounds, chemical vapors, cigarette, pet, and/or flatulence odors call for the use of an activated carbon (charcoal) or other type of filter instead of or in addition to a HEPA filter.[8]

Specifications
HEPA filters, as defined by the United States Department of Energy (DOE) standard adopted by most American industries, remove at least 99.97% of airborne particles 0.3 micrometers (µm) in diameter. The filter's minimal resistance to airflow, or pressure drop, is usually specified around 300 pascals (0.044 psi) at its nominal volumetric flow rate.

The specification usually used in the European Union is the European Norm EN 1822:2009. It defines several classes of HEPA filters by their retention at the given most penetrating particle size (MPPS):

Today, a HEPA filter rating is applicable to any highly efficient air filter that can attain the same filter efficiency performance standards as a minimum and is equivalent to the more recent National Institute for Occupational Safety and Health N100 rating for respirator filters. The United States Department of Energy (DOE) has specific requirements for HEPA filters in DOE regulated applications. In addition, companies have begun using a marketing term known as "True HEPA" to give consumers assurance that their air filters are indeed certified to meet the HEPA standard.[9]

Products that claim to be "HEPA-type", "HEPA-like", "HEPA-style" or "99% HEPA" do not satisfy these requirements and may not have been tested in independent laboratories. Some of these sub-par quality filters may come reasonably close to HEPA filtration, while others will fall significantly short, making them truly inferior.[10]

Biomedical applications
HEPA filters are critical in the prevention of the spread of airborne bacterial and viral organisms and, therefore, infection. Typically, medical-use HEPA filtration systems also incorporate high-energy ultra-violet light units to kill off the live bacteria and viruses trapped by the filter media. Some of the best-rated HEPA units have an efficiency rating of 99.995%, which assures a very high level of protection against airborne disease transmission.

3M Cartridges & Filters for Worker Health & Safety
« Last Edit: April 30, 2018, 04:45:56 PM by Jhanananda »
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Naman

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Re: Immune-mediated inflammatory diseases
« Reply #22 on: August 12, 2018, 10:51:13 AM »
Its been long since i visited GWV. How is your health Jhanananda?

Jhanananda

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Re: Immune-mediated inflammatory diseases
« Reply #23 on: August 13, 2018, 04:40:47 PM »
Thank-you, Naman, for expressing your concern for my health.  It took me about 8 years to work through my health problems, which turned out to be off-scale allergies to local pollens, molds, and terpines.  It turned out all I had to do was sleep every night with purified air from a HEPA filter.  My health has improved immensely.  Even arthritic joint pain is way down.
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DDawson

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Re: Immune-mediated inflammatory diseases
« Reply #24 on: August 13, 2018, 05:54:55 PM »
Good to hear you're hanging in there and feeling better.  What a struggle life is sometimes, but a chance to use our enginuity and learn.  Jhanananda, what do you think of the keto diet? 

Jhanananda

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Re: Immune-mediated inflammatory diseases
« Reply #25 on: August 14, 2018, 04:56:53 PM »
Thanks, DDawson.  The ketogenic diet really did nothing for my diabetes, and other health issues.  I finally got all of my vitals normalized, even my blood sugar, by getting my allergies under control.  At first it took 3x normal dose of antihistamines to do so; but it lead to kidney disease.  Then I switched to filtering the air I breath when my body sleeps with a HEPA filter.  At that point I stopped taking antihistamines. 

Along the way I started losing 5lbs (2KG) per month.  At first losing the extra weight that I had gained after moving to Prescott, AZ was nice.  However, when I got to 160lb (80KG) I felt like I was wasting away.  So, I started adding carbohydrates to my diet.  When I got to about 50g of carbohydrates per meal my weight increased to 165lbs, and it has now stabilized.
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Naman

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Re: Immune-mediated inflammatory diseases
« Reply #26 on: August 17, 2018, 10:22:04 AM »
Such a hard painful work it is sometimes to find the cause of physical ailment which no other is able to identify or have a cure for.
Im so glad that u finally were able to pin point the cause and work it all out for good.

Jhanananda

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Re: Immune-mediated inflammatory diseases
« Reply #27 on: August 17, 2018, 04:38:03 PM »
Thanks, Naman, yes, it took me 8 years to realize that both the medical model and the natural health model of healing are deeply flawed.  I plan to write a book on my findings, to help others.
« Last Edit: August 18, 2018, 04:16:20 PM by Jhanananda »
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Naman

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Re: Immune-mediated inflammatory diseases
« Reply #28 on: August 22, 2018, 06:00:51 AM »
It wud be really great if u will sum it up all for the rest of the humanity to learn from.

Jhanananda

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Re: Immune-mediated inflammatory diseases
« Reply #29 on: August 25, 2018, 04:17:35 PM »
Thanks, I am working on it.
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