I have heard accounts of adepts being highly effected by small amounts of substances and some who experience no effect all like Neem Karoli baba from LSD.
Funny you would mention that. While pot makes me anxious, I am almost unaffected by (or it takes very large doses to notice): magic mushrooms, salvia, and DMT/Ayahuasca. I haven't tried LSD since I was in high school, so who knows. Something about constantly moving into bliss, joy and ecstasy, and becoming saturated in first jhana - perhaps this conditions the brain receptors that would normally trigger psychedelic responses? I don't know. I remember reading about people slipping Neem Karoli Baba hits of acid - which was not weak in those days - and it had zero effect on him. We know he was absorbed in the All at all times, so there ya go....
Before I got targeted by drone systems (Havana Syndrome) over my house....
I met a homeless man here in Boulder, maybe 20-25 years ago, named Eric. He was VERY paranoid, but not on drugs or alcohol. Eventually he told me that he'd been a Naval intelligence specialist, and that he'd witnessed large amounts of heroine and marijuana being offloaded Navy ships in the port at Long Beach, CA - in the late 80's. He tried going up the chain of command to report this recurring activity, and ended up not only being kicked out of the Navy, but having his identity wiped to the point where he was a non-person. This pissed him off, so he used his computer skills to join a hacking group that eventually destroyed the 5 Eyes surveillance grid (called Project Echelon), costing "governments" (i.e., citizens) countless billions of dollars and years of development. So they really went after him at that point. He said that a series of "girlfriends" were actually his handlers. In running away from them he became homeless, and he would wake up under park benches and a paper sack filled with dynamite would be placed by his head - just tons of stories like that. The first time he returned home to the Michigan Peninsula, his sister's house burned down a day after he arrived, such that he had to get everyone out through the garage. He was kept homeless and personless for about ten years, and has flown well under the radar ever since. He eventually found me on social media and I've been following his exploits down through the years - he became an activist for the wild buffalo, followed the hippie jamboree circuit and lived out of his car for many years, then got married but his wife died of cancer shortly thereafter, and now he's trying to live a normal life.
I'm not wanting to start a big discussion here (sensitive to staying on-topic for this thread and also the mission of supporting contemplatives in their interior work), but wanted to tell this story as a validation that I know targeting is real, that it is far more pervasive than anyone on the outside realizes, and that it is an indication of the darkness that lurks in the world's institutions. I'm glad that you've made it to the other shore, David.