The 10 Deadliest Outbreaks in U.S. History — Revisited By Dan Flynn | April 4, 2012
In order of Magnitude
1.
Typhoid fever, 1924-25Oysters from Long Island, NY, held in polluted waters, sickened more than 1,500 in New York, Chicago, and Washington, D.C.; 150 died.
2.
Typhoid fever, 1903A public water source in Ithaca, NY, was polluted from a dam construction site, resulting in typhoid outbreak involving 1,350 people; 82 were killed, including 29 Cornell University students.
3.
Streptococcus, 1911Raw milk delivered door-to-door in the Boston area was responsible for a strep outbreak; 48 people died.
4.
Listeria, 2011“Rocky Ford” cantaloupes from Colorado became contaminated, probably in the packing facility, sickening at least 146 in 28 states; 36 died.
5.
Listeria, 1985Mexican cheese made by a Los Angeles company sickened mostly Hispanic women, many who were pregnant; 28 died.
6.
Streptococcus, 1922Raw milk delivered door-to-door in Portland, OR was contaminated; 22 killed.
7.
Listeria, 1998Ball Park hot dogs and Sara Lee deli meats were recalled after Listeria was found in the Michigan processing plant; 21 killed.
8.
Botulism, 1919Canned ripe olives from California sold to inland states were contaminated and caused outbreaks in three states; 19 died.
9.
Salmonella Typhimurium, 2008-09Peanut butter and paste contaminated with S. Typhimurium caused at least 714 illiness in 46 states; 9 killed.
10.
Listeria, 2002Sliced turkey meats from Pilgrim’s Pride were responsible for a multiple state outbreak; 8 killed.