One of the things Nietzsche said was, "God is dead."
I do not take this as a statement of irreligion, but as an explanation of the time we're living in.
In our time, we have religions that do not have any inner significance. We have human beings who have no conception of the sacred. What is most important to know about our time is that, if you are a reasonable thinking human being, it is rational for you to be irreligious. In other words, I am making no value judgment about people who live in the 21st century and believe in nothing: in fact, I am saying I agree with them.
But what all this means for those of us interested in the mystic life, is that if we are to engage with this world wholly and honestly, there is a long pre-journey that comes before the real one. On one level, we must become scholars of religion first, as secularists, and then proceed to go deeper and deeper on our way to an inward religion.
This trek involves many transformations. We must change our views and values again and again. And, in dealing with the complexities of the world, this may itself be what transforms us.
For example, let us say I agree with an atheist on one day, who says that religion has no place in the state. But, then I read St. John of the Cross. How do I reconcile these? I cannot make them easily compatible. A powerful emotional and intellectual refinement is needed to be able to hold these (generally speaking) contradictory views.